Job title: Senior Scientist
I am a research scientist within the Chemical, Biological and Radiological division at Dstl Porton Down, and I am currently undertaking a PhD in collaboration with the London School of Hygiene and Tropical Medicine. My PhD project is developing antibody based combination therapies for melioidosis, a neglected tropical disease caused by the bacterium Burkholderia pseudomallei. This project involves creating an antibody-antibiotic conjugate which has potential to deliver antibiotic to the site of infection, improving current antibiotic therapies for melioidosis. I have an extensive background at Dstl in monoclonal antibody generation which is now being applied to therapeutics for bacterial diseases. My future work will involve further investigation of therapeutic antibodies including developing antibody-drug conjugates for other bacterial diseases.
Antibody-Antibiotic Conjugate for the Treatment of Melioidosis 12:10 pm
Antibodies have been assessed and demonstrated ability to opsonise Burkholderia pseudomallei in vitro as well as demonstrating anti-virulence effects Two antibiotics have been successfully incorporated into a cathepsin cleavable linker, the cleaved products are functional against bacteria in vitro A down-selected antibody and antibiotic-linker have recently been incorporated into a full antibody-antibiotic conjugate and is…Read more
day: 1st ADCs Outside of Oncology Day