Antibody-Antibiotic Conjugate for the Treatment of Melioidosis
Time: 12:10 pm
day: 1st ADCs Outside of Oncology Day
Details:
- Antibodies have been assessed and demonstrated ability to opsonise Burkholderia pseudomallei in vitro as well as demonstrating anti-virulence effects
- Two antibiotics have been successfully incorporated into a cathepsin cleavable linker, the cleaved products are functional against bacteria in vitro
- A down-selected antibody and antibiotic-linker have recently been incorporated into a full antibody-antibiotic conjugate and is currently being investigated in macrophage cell infection assays
Speakers:
I am a research scientist within the Chemical, Biological and Radiological division at Dstl Porton Down, and I am currently undertaking a PhD in collaboration with the London School of Hygiene and Tropical Medicine. My PhD project is developing antibody based combination therapies for melioidosis, a neglected tropical disease caused by the bacterium Burkholderia pseudomallei. This project involves creating an antibody-antibiotic conjugate…Read more