Antibody-Antibiotic Conjugate for the Treatment of Melioidosis

Time: 12:10 pm
day: 1st ADCs Outside of Oncology Day


  • Antibodies have been assessed and demonstrated ability to opsonise Burkholderia pseudomallei in vitro as well as demonstrating anti-virulence effects
  • Two antibiotics have been successfully incorporated into a cathepsin cleavable linker, the cleaved products are functional against bacteria in vitro
  • A down-selected antibody and antibiotic-linker have recently been incorporated into a full antibody-antibiotic conjugate and is currently being investigated in macrophage cell infection assays